The Anti-IKK beta Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to IKBKB, IKK-beta, IKK2, IKKB, and Inhibitor of nuclear factor kappa-B kinase subunit beta. This antibody recognizes Human antigen. The Anti-IKK beta Antibody has been validated for the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) detection. Tested with WB, IHC-P in Human.
Background: IKBKB(Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Kinase of, Beta), also known as IKKB or NFKBIKB, is a protein that in humans is encoded by the IKBKB gene. This gene is mapped to chromosome 8p12-p11 by FISH. It is found that mutations in IKK2 had a more pronounced effect upon NFKB activation than did comparable mutations in IKK1. The activity of various antiinflammatory agents on the IKK complex has been texted, it has been found that aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo by binding to IKK-beta to reduce ATP binding